Castleman’s disease is a rare clinico-patholological entity characterized by non-neoplastic lymph node hypertrophy. Its incidence and etiology is not known, but it has been found in association with Kaposi’s Sarcoma. We report a case of 34 years old female patient with history of solitary neck swelling (left Neck) for 10 months without any other presenting symptoms in the nose and throat. The neck node was present at level 2b, measuring 3x2cm, firm, painless, non-tender and mobile beneath the left Sternocleidomastoid muscle. Lymph node histopathological biopsy revealed Castleman’s disease. USG Whole abdomen, Chest X Ray, CECT Thorax were normal. This case report highlights the clinical, histological aspects of Castleman’s disease.