Background: Tetanus remains a significant cause of maternal and neonatal mortality in Nigeria, particularly in underserved areas. The Tetanus-diphteria (Td) vaccine is a key preventive intervention and recommended during pregnancy to protect both mother and newborns. Despite its proven benefit, the uptake of Td vaccine remains suboptimal in many rural communities. This study aimed to assess the prevalence and identify determinants of Td vaccine uptake among pregnant women attending antenatal care at primary health care centers in Kondiko town, Gwaram Local Government Area, Jigawa State.

Methods: A descriptive cross-sectional study was carried out among 206 respondents that were recruited from the clinic and data were collected using semi-structured interviewer administered questionnaire. Data was analyzed using SPSS Version 21.0, α level of significance was set at 5%.

Results: The age of the respondents ranges from 14 to 49 years and the prevalence of Td vaccine uptake among the respondents was 65% but 48.5%, 89.3% had good knowledge, attitude respectively and 87.9% had poor perception of Td vaccine uptake while educational level, number of antenatal visits and cultural factors are the determinants.