Background: Guillain‑Barré Syndrome (GBS) is an acute autoimmune demyelinating neuropathy resulting in rapid-onset muscle weakness, sensory deficits, and frequently impaired respiratory function. While immunotherapy (e.g., IVIg, plasmapheresis) is the cornerstone of acute medical management, physiotherapy plays a critical role in restoring motor function, mobility, and independence throughout recovery.

Objective: To systematically review clinical evidence on physiotherapy and structured rehabilitation interventions in GBS and their effects on functional outcomes, strength, mobility, respiratory function, and disability.

Methods: A systematic literature search was conducted across PubMed, PMC, and other open-access databases for clinical trials, case reports, and systematic reviews assessing physiotherapy interventions in GBS. Both acute and chronic phase rehabilitation outcomes were considered.

Results: Evidence supports that exercise-based rehabilitation programs—incorporating progressive resistance training, functional task practice, endurance exercises, balance training, and respiratory muscle training—can improve motor strength, functional mobility, independence, and cardiopulmonary function in GBS patients. A randomized controlled trial found that high-intensity exercise led to significantly greater improvements in functional independence compared with low-intensity programs. Case studies and structured rehabilitation report also demonstrate notable improvements in strength, balance, and disability scores. However, study heterogeneity and limited high-quality randomized trials restrict definitive protocol recommendations.