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VOL. 10, ISSUE 3 (2025)
Toxicological evaluation of low dose methyl 2-benzimidazole carbamate (carbendazim) fungicide on male albino rats (Rattus norvegius)
Authors
Nirmal Kumar
Abstract
Methyl 2-benzimidazole carbamate (carbendazim)
is a synthetic fungicide used against organisms that cause different types of
plant diseases. It is widely used as a preservative in leather, paint, textile,
fruit, and paper industry. It is also used as an anticancer drug in clinical
medicine. To evaluate the low dose toxicity of this compound in mammalian
tissues, carbendazim was administered to male albino rats (Rattus norvegius)
at 5, 10, 25, and 50 mM doses intradermally. At 6, 12 and 24 hours, blood
samples were collected from the animals for analysis of biochemical and hematological
parameters including serum enzyme activities. The findings indicated that
carbendazim caused a decrease in serum total protein, ALT, AST, ALP and amylase
activities. GGT activity decreased by 6hr and increased by 12hr in a
dose-related manner. Carbendazim caused an increase in serum cholesterol, uric
acid, glucose, and creatinine content while serum phosphorous content
decreased. Mean hemoglobin, WBC, E, and platelet counts increased and total
RBC, N and L counts decreased. Tissues (brain, heart, liver, kidney, and
testis) taken from 50mM dose administered rat for histopathological examination
revealed liquefactive necrosis of blood vessels, fibrosis, dialated parenchyma,
hemorrhage, and edema in the brain tissue. In heart, necrosis and loss of
nuclei in cardiac muscle cells were noted. Low dose level of carbendazim
causes toxicological effects in the rat tissues.
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Pages:13-17
How to cite this article:
Nirmal Kumar "Toxicological evaluation of low dose methyl 2-benzimidazole carbamate (carbendazim) fungicide on male albino rats (<i>Rattus norvegius</i>)". International Journal of Advanced Research and Development, Vol 10, Issue 3, 2025, Pages 13-17
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