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VOL. 10, ISSUE 1 (2025)
Menstruation problem due to polycystic ovarian syndrome: Himalayan medicinal plant, Zanthoxylum armatum, DC, (Timur), may block CYP-17, 5α-reductase and human androgen receptors
Authors
Vineeta Sharma, Suraj Joshi, Suman Bhandari, Shankar Mondal
Abstract
Polycystic ovarian syndrome (PCOS) is primarily an endocrinological
disorder responsible for anovulatory related infertility. PCOS is characterized
by symptoms like hyperandrogenism, irregular menses and chronic metabolic
syndromes. PCOS manifests due to overexpression of genes like CYP-17
[Cytochrome P-450 superfamily gene] along with 5α-reductase and human androgen
receptors. Therapeutic drugs like metformin, spironolactone and cyproterone
acetate are used to treat PCOS butit shows side effects. The Himalayan
medicinal plant Zanthoxylum armatum, DC, [ZA]is traditionally used in Ayurveda
for many illnesses like asthma, stomach-ache and menstrual disorders. In this
study, a comparative screening was done for least binding energy (∆G) of
phytochemicals for it potential to inhibit the target receptor (CYP-17,
5α-reductase and human androgen receptor) with the reference drug. PyRx and
Biovia Discovery studio visualizer 2021softwares were used for virtual
screening and analysis. The potential oftoxicity ZA phytochemicals was also
screened using Swiss ADME software. Sixteen molecules of ZA have shown binding
affinity with CYP-17, 5α-reductase and human androgen receptors. Phytochemical
lupeol has shown the least binding energy [DG] -10.8kcal/mol with CYP-17, while hesperidin showed DG
-12.2kcal/mol with 5α-reductase and Asarinin exhibitedDG
-9.8kcal/mol with human androgen receptors. The drugs metformin, spironolactone
and cyproterone acetate have shown DG ranging from -5.0 to -11.2kcal/mol. Toxicity study showed that
12phytochemicals followed Lipinski’s rule of five. In summary, ZA
phytochemicals have exhibited significant least binding energy as compared to
current drugs. Thus, these phytochemicals may be used as potential lead drug
molecules for target-specific in-vitro studies.
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Pages:46-55
How to cite this article:
Vineeta Sharma, Suraj Joshi, Suman Bhandari, Shankar Mondal "Menstruation problem due to polycystic ovarian syndrome: Himalayan medicinal plant, <i>Zanthoxylum armatum</i>, DC, (Timur), may block CYP-17, 5α-reductase and human androgen receptors". International Journal of Advanced Research and Development, Vol 10, Issue 1, 2025, Pages 46-55
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