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VOL. 10, ISSUE 1 (2025)
Haematological alterations induced by the oral doses of iron oxide and aluminium oxide nanoparticles in Wistar rats
Authors
Nisha Kohli, Seema Agarwal, Pooja Mehra
Abstract
The present study was designed to know the
haematological alterations caused by nano-iron oxide and nano- aluminum oxide
in Wistar rats in a repeated dose study for 90 days. 35 Wistar rats were
divided randomly in 2 group viz. control and test. Control group contain
20 and tests group contain 15 experimental animals. From day 0 and till 90 day
of the experiment, control group was provided with standard feed and RO water
and in treated group along with standard feed and RO water, nano-iron oxide and
nano-aluminium oxide mixed in distilled water was also gavazed at the dose half
of the NOAEL dose viz. 15mg/kg body weight and 3mg/kg body weight
respectively. Various haematological parameters were studied at day 0, 30, 60
and 90 of the experiment. And the results showed that long term exposure of
iron and aluminium nanoparticles at half of their dose cause mild to moderate
decrease in the mean Hb, mean RBC count, mean TLC, mean MCH and mean MCV in
rats of treated group as compared to control group.
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Pages:6-11
How to cite this article:
Nisha Kohli, Seema Agarwal, Pooja Mehra "Haematological alterations induced by the oral doses of iron oxide and aluminium oxide nanoparticles in Wistar rats". International Journal of Advanced Research and Development, Vol 10, Issue 1, 2025, Pages 6-11
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