The Covid-19 pandemic can be termed as one of the biggest challenges which confronted mankind in the present times. New waves of Covid-19 wreaked havoc in various countries. If the virus continues to spread, the consequences would be devastating. This paper delineates the major challenges faced by the developing countries in context of the pandemic. These included emergence of deadlier and more contagious variants, shortage of healthcare resources, vulnerability of densely populated areas, increasing poverty, unemployment, reverse migration, exacerbating gender inequalities and impact on education.