DNA forensic laboratory is a laboratory that specializes in the analysis of DNA (deoxyribonucleic acid) for forensic purposes. DNA evidence can be collected from a variety of sources, including blood, hair, skin, and saliva, and can be used to identify individuals, link suspects to crimes, and exonerate the innocent. In a DNA forensic lab, the collected evidence undergoes a number of processes, including extraction, amplification, and analysis, in order to generate a unique DNA profile that can be compared to reference samples. The results of these analyses can be used in criminal investigations, court proceedings, and other legal matters. This paper will be discussing introduction, historical background DNA, types of DNA, problems, challenges, DNA importance, legal framework, DNA solve cases, remove challenges, conclusion.