Mucilage'is a complex heterogeneous polysaccharide. Polysaccharides have emerged as an important class of bioactive natural products and widely used in food, cosmetics, textiles, and pharmaceutical systems for various purposes, such as thickener, stabilizer, emulsifier, excipient and gelling agent. In addition, many studies elucidate that polysaccharides isolated fiom plants have antioxidative activities. Hetero-polysaccharide mucilage was extracted from the seed coats of different citrus rootstocks viz. Rough lemon, Sachtion citmmelo and Yuma citrange for investigating its biochemical and molecular properties. In the proposed research work, soxhlet extraction methodology is to be employed for the extraction of lemon seed mueilage and that extract is to be used for proposed formulation to improve the solubility of less soluble drug. Seed mucilage of Lepidium sativum (Cruciferae) was used to prepare fast disintegrating tablets and formulated. Tablets were compared with tablets prepared using synthetic disintegrant such as soditun starch glycolate, kyron T314 and ac-disol. The results showed that disintegration and mean dissolution time for batch containing 10% mucilage was better than other tablets prepared using different synthetic disintegrating agent.