During the past few years, there was an increasing the interest in the development of novel drug delivery system in these novel drug delivery system. These developed novel drug delivery systems are beneficial in term of improved patient compliance, overall therapeutic effect with significant level. When these systems are designed to overcome the problems with conventional methods of drug delivery i.e. the drugs which can degrade in GI treat or degradation before reaching to the site of action could be effectively delivered with pulsatile as gastro resistant drug delivery. One of the novel drug deliveries is transdermal drug delivery system. Wound healing is very complex process with many potential factors that can delay healing of wound. It may be caused by an act such as a gunshot, chemicals, cut, heat, cold pressure, fall or surgical intervention by infectious diseases. Samudraphen is drug from marine origin which is also referred as cuttle fish bone. This is an internal shell of Sepia Officinalis belonging to the Sepiodia. Cuttle bone contains Chitin, Chitosan, amino acids, and calcium carbonate. Which makes the successful development of formulation which could be used to hasten wound healing and induced cell migration and proliferation, and antibacterial activity. The description about the Samudraphen is available from Samhita period.