The present study was conducted to develop a simple and precise analytical method for the estimation of ticagrelor in tablet formulation. Reverse Phase HPLC was used for method development and validation studies of ticagrelor. The optimum chromatographic conditions comprised of C18 column (Enable; 4.6 x 250mm, 5mm)) as the stationary phase and acetonitrile and 0.01M phosphate buffer in the ratio of 60:40 v/v as the mobile phase. The flow rate was 1 ml/min with detection at 230 nm and a run time of 10 min. The retention time of ticagrelor was 5.45 min. The linearity studies indicated that the range of the developed method was 50-150 µg/ml with a correlation coefficient of 0.999. The method was specific with a percent mean recovery was found to be 100.6 %. The % RSD in the precision studies was 0.069. The validated method was applied to conduct the assay of ticagrelor in tablets with a percent mean recovery of 98.98 %.Conclusion: The developed and validated RP-HPLC isocratic method was simple, accurate and precise as per the ICH guidelines. It was suitable for the analysis of ticagrelor in bulk and tablet formulation.