Cisplatin are anticancer drug which action with potent and effective for chemotherapy against solid tumors. These drugs show effective chemoprevention in chemotherapy and also lead to several manipulations and cytotoxicity in tissues. In present studies, sub-lethal doses of Cisplatin (LC50/10 for 96 hours) were given to freshwater bivalves, Corbicula Striatella. For 45 days. The acid phosphatase activity was determined from various tissues of control and experimental bivalves by method of Gutman and Gutman. It was found that acid phosphatase activities were increased in various tissues with increased period of exposure to anticancer drugs in experimental bivalves. It was also observed that acid phosphatase activity increased in various tissues in Cisplatin treated bivalves.