The Yamuna River is the second largest tributary of Ganges. It is originating from the Yamunotri Glacier at a Hight of 6,387 meters on the southwestern slopes of Banderpooch peaks of the lower Himalaya in Uttarakhand. It travels a total length of 1,376 kilometers. It is one of the most polluted river in India. Yamuna river flows only for 54 kilometers from Palla to Badarpur through Delhi, The 22 km stretch from Wazirabad to Okhla, Which is the less than 2 percent of the river length of 1370 kilometers from Yamunotri to Prayagraj, accounts of about 76 percent of the pollution level in the river. This 2 percent stretch from Wazirabad to Okhla have maximum discharge of untreated industrial and domestic waste. The undeveloped sewerage system and unavailability of sewerage lines in Delhi are affecting the water quality of Yamuna River by falling of untreated sewage water through the open drains. The 21 drains discharge around 850 MGD (million gallons per day) of sewage into the Yamuna every day. Looking to the severe condition of the sewerage system, it was decided to carry out a study to analyze the effect of open drainage system on water quality (Physico-chemical parameters) of Yamuna River.