The microbial infections that once were easily treated are becoming untreatable in these days. The major cause for this problem is the growth of antimicrobial resistance among the microorganisms. Antimicrobial resistance possess serious threat to health in India and worldwide. Resistance arise through one of three ways; natural resistance in certain types of bacteria, genetic mutation or by one species acquiring resistance from another. Within four years following the introduction of Penicillin during the Second World War, occurrence of resistance strain was reported. Inappropriate or incorrect use of antimicrobial drugs and premature treatment interruption can cause drug resistance. The multiplicity and non-specificity of efflux pumps and occurrence of resistance-conferring genes in non-pathogenic bacteria hint at some other role of antibiotics in evolution. It is also believed that bacteria sense antibiotics as an environmental stress.