An amplifier is utilized to expand the intensity of a signal. This is done by utilizing vitality from a power supply. An investigation is done in order to compare the high-end instrumentation amplifier which are frequently utilized in many advance applications. Amplifiers can be utilized to enhance the quality and determination of very minute signals related to medical field, telecommunication, TVs, DVRs, PC screens, set-top boxes and video signals from surveillance cameras. This paper discusses about instrumentation amplifier, its advantages, and applications and also presents previous work by various researchers.