The current study is conducted to investigate mental well-being & optimism among people living with HIV/AIDS. The sample of the study consisted of 100 people living with HIV/AIDS. And the patients were equally distributed on the basis of gender (50 Male and 50 Female). The Warwick-Edinburgh Mental Well-being Scale (WEMWBS) and Life Orientation Test-Revised version (LOT-R; Scheier, Carver, & Bridges, 1994) was used. Pearson’s correlation and t-test were employed for the analysis of data. The results indicated that there is a significant positive correlation between mental well-being and optimism among people living with HIV/AIDS. The results as well revealed that there is a significant difference in mental well-being & optimism among people living with HIV/AIDS with respect to their gender.