Complementary and alternative medicine (CAM) is widely used both as a supplement to conventional or mainstream health care and as part of traditional health care systems and practices. The present work is aimed at studying the knowledge, attitude and practice of CAM by selected adult population living in Bangladesh. A cross-sectional descriptive survey was conducted from September 2016 to March 2017. A total of 300 selected adult population in Gazaria, Munshiganj district. Data were collected by semi structured interviewer administered and pre-tested questionnaire. Among the respondents 153(51%) were male and 147 (49%) were female with mean age of 38.36 years. Mean± SD 38.36±12.548. As regards educational level of the most respondent was 26.7% primary, 23.3%, illiterate, 20.0% SSC, 15% HSC, 10% degree & 5% was masters and above. The study population was 300 among them the highest 90.7% was married and lowest 9.3% was unmarried. The most of the respondents was service holder 30.7%, housewife 20%, farmer 10% and others professional 9.7%. Study result showed that the highest majority family income 44.7% was ranged from BDT20001-BDT30000 taka and lowest 4.7% was BDT50001-BDT60000 taka. Among the study population majority of the respondents, 95.0% did not follow WHO recommended diet chart and 90% did not perform physical exercise. Majority of the respondents lead physically stressed life 75.0%, were mentally stressed 20% and sedentary lifestyle 5%. Among the respondents 95% access TV, 65.3% read newspaper regularly. Among the respondent knowledge level on Complementary and alternative medicine (CAM) showed that about half of the study population 50% had average knowledge, 25% had good knowledge, 15% had poor knowledge, 5% had very poor knowledge 5% had also excellent knowledge on CAM. The study focuses on the awareness of the respondents on CAM. The study showed that highest number of respondents got information’s 50.0% from family members, friends or relatives, 26.7% from mass media, 10% from educational academies and 8.3% from others sources. Attitude based statements were presented on a Five-point Likert Scale showed that, This study showed that 30% respondents attitude on scientific basis of CAM were positive, 88.3% were strongly agreed that conventional medicine uses with CAM are beneficial to patient and 80% opined that CAM are easy to access. The majority i.e. 98% strongly agreed to stop unethical practices and 65% suggest to mass media should show awareness raising program on CAM regularly. Overall, there is a positive attitude towards CAM. The study showed that highest number of respondents 97% practices CAM to cure & to prevent various diseases. Among the respondents 35.1% practices traditional healing method. Present study showed that 45.1% practices CAM for lower prices, 45.4% practices for physical debility, 62.1% uses for chronic cases and 39.6% uses CAM from quack like non-qualified practitioners. This study shows that there was statistically significant association between the knowledge level and educational qualification of the study population to CAM.