Depression is more common and serious medical illness that negatively affects person. The course of depression is variable from person to person. An individual suffering with depression sometime shows the symptoms of Anorexia Nervosa. The present study was design to compare the depression and Anorexia Nervosa among adolescents. The study was conducted on 200 adolescents from which 100 subjects were males and 100 were females. For collecting data, Beck Depression Inventory- Second Edition (BDI-II) by Aaron, T. Beck, Robert, A. Steer & Gregory K. Brown was used to assess Depression and Anorexia Test was used to assess Anorexia Nervosa which was designed by V.L. Chouhan and A. Banerjee. It was found that a significant positive relationship between Depression and Anorexia Nervosa among adolescents. It indicates as the depression increases Anorexia Nervosa also increases.