Syzygium cuministem bark was collected from near by area in Bijapur district, Karnataka in the month of January 2014. It was processed and subjected for soxhlet extraction using methanol followed by distilled water. Phytochemical screening of crude methanolic extract has showed the positive tests for Phenols, Glycosides, Saponins and Steroids. The water extract contains Phenols, Glycosides, Saponins and Steroids. Both the extracts were tested for their antibacterial activity using two gram positive and two gram negative organisms and two fungal species at different concentrations. The results were compared with a standard drug. Both the extracts have exhibited encouraging results.