Kerala is rich with well equipped, modern specialty hospitals. Like any other industry, health sector is undergoing broadest set of changes and also facing severe competition in every aspect of its service and private health care institutions are indeed more concerned about profit as well. The development and maintenance of efficient work force is a major concern particularly in healthcare organizations. Nurses are considered as the backbone of any healthcare system for their honorable unparalleled service. Hence it is one of the basic prerequisite of organizational management of healthcare institutions to monitor and sustain the level of personal and organizational factors that has a direct impact on the quality of performance of nurses. Data was collected from a total of 200 nurses working at both government and private hospitals. Two-way ANOVA was used to examine the interaction effect of subjective well-being and organizational commitment on work engagement. The results revealed that work engagement is being significantly influenced by organizational commitment and subjective well being of nurses.