Most of topical preparations are meant to be applied to the skin. The basic knowledge of skin and its physiology function and biochemistry is very important for designing topicals. It is suggested that acidity of the skin helps in limiting or preventing the growth of pathogens and other organisms. Delivery systems are designed chemical entities that carry a chosen active compound and allow its approach to its site of action. Drug delivery system serves as a strategic tool for expanding market share, extending the product life cycles and generating newer opportunities which has become increasingly important in the pharmaceutical industry. The definition of drug delivery system as we describe them is quite broad & includes the carrier formulation, (i.e., gel, emulsion, suspension etc.) as well as particulate or molecular carriers (i.e., niosomes, liposomes, transfersomes). The advanced drug delivery system extends the proprietary status of drugs facing patent expiration, thereby providing increased profitability.