This paper includes result of investigation of botanicals used against various ailments in Dhule district. Total 20 angiospermic species belonging to 18 genera and 15 families reported. Various plant parts such as leaves, roots, stem, fruits, seeds and flowers etc. these are employed in form of different recipes like extract, decoction, juice, powder, ash etc. and supplemented occasionally with milk, honey, jaggery. Although there are traditionally reported useful. They must be testified on scientific line involving chemical, biological and clinical screening.