Self-esteem is a fundamental human motive that all people strive to protect and enhance (Rosenberg, 1989). Baumeister et al. (2003) remarked that self-esteem is a highly desirable psychological source of positive behavior which may include academic achievement. Stress is the physiological reaction which occurs when people perceive an imbalance between the level of demand placed upon them and their capability to meet those demands. The current investigation was designed to study the interrelationship between self- esteem, perceived stress and academic performance among adolescents. The sample for the current investigation consisted of 40 adolescents (where 20 are males and 20 are females) in the age group of 16-18 years of tricity of Panchkula, Mohali and Chandigarh. For this purpose, the Self- Esteem Scale (Rosenberg, 1965) and Perceived Stress Scale (Cohen & Williamson, 1988) were administered to the sample. The average score of the last two year’s examination was taken as the score for academic performance. Inter- correlational analysis was used for statistical analysis. Results were discussed in terms of its implications.