Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that activates diverse array of proteins and is considered to be neuroprotective in nature. Neurodegenerative diseases such as Alzheimer, Amyotrophic lateral sclerosis and Parkinson’s disease are becoming world’s most alarming public health challenges. In fact, the mechanisms leading to neurodegeneration are not fully understood, so the diseases arising from it have no treatment so far. In this review, we introduce the structural features of Nrf2 and briefly depict its function in providing neuroprotection against different neurological diseases. The information presented here may be useful in the design of future experimental research and increase the likelihood of using Nrf2 as a therapeutic target for neurodegenerative diseases in the future.