The efficacy of using of lydasa in treatment of non-traumatic intracerebral hematoma studied in two identical matched by sex and age groups were treated by conventional standards. In the group of patients who received conventional treatment with additional lydasa medication resorption of intracerebral hematomas, recovery of neurological deficits occurred with accelerated pace compared to other similar group of patients who had not recieved lydasa. The results indicate the expediency of using of lydasa in treatment of intracerebral hematomas with small volumes.