This paper discusses Defamiliarization in Amit Chaudhuri’s debut novel A Strange and Sublime Address. Defamiliarization is a literary technique that compels readers to see the commonplace, known things in a weird and unfamiliar way. It retards the very act of looking at everyday words or objects, in order to force the listener or reader to reexamine it. Amit Chaudhuri makes his novel (A Strange and Sublime Address) so praiseworthy and attention-grabbing by using the technique of defamiliarization, even when there are no gripping stories to tell, no momentous events to describe and no emotional outbursts. He has a deep attachment to the culture of his country, especially that of Bengal.