The influence of physico-chemical properties of Satna river were investigated for one year from June 2014 to May 2015. Analysis of physico-chemical parameters like water temperature, pH, rainfall, DO, BOD, EC, Total alkalinity, Total hardness, chloride, SO4, Fe has been made during the investigation period. Results reveal all parameters are within the permissible limits. It was quite evident from the findings that the quality of river water was suitable for drinking, agriculture purposes.